Manufacturer Provide CAS 220127-57-1 Anti-Cancer Imatinib Mesylate Powder

Introduction

Product Name: Imatinib Mesylate

Other Name :Imatinibmesylate

CAS NO:220127-57-1

Purity: 99%min
Appearance:White crystalline powder

Molecular formula:C30H35N7O4S

MW:589.71

Boiling Point :214-224°C

Storage :Keep in dark place,Inert atmosphere,Room temperature

Imatinib Mesylate is a specific tyrosine kinase (abl, c-kit, and PDGFR) inhibitor and is reported to sensitize cells to radio- or chemo-therapy. When tested with Y-79 and WERI-RB-1 Rb cell lines, imatinib mesylate treatment decreased the cell proliferation and invasion with the concentration of 10 μM . In osteoblast cells, administration of imatinib mesylate decreased osteoclast development via stimulating differentiation, inhibiting proliferation and survival .

In dog model with mast cell tumor, administration of imatinib mesylate at a dose of 10 mg/kg daily for 1-9 weeks reduced tumor growth via inhibiting tyrosine kinase .