Pramipexole Hydrochloride

Pramipexole Hydrochloride CAS:104632-25-9

Two major curative features of pramipexole hydrochloride in the treatment of Parkinson's disease:
1. Relieve the motor symptoms of Parkinson's disease: Parkinson's disease is caused by the loss of dopaminergic neurons in the substantia nigra causing a lack of dopamine, resulting in a series of symptoms such as tremor, muscle rigidity and slow movement. Pramipexole hydrochloride can act highly selectively on dopaminergic D2 and D3 receptors, stimulate the release of dopamine in the brain, and improve motor symptoms. The study by Shannon et al. showed that pramipexole monotherapy in early Parkinson's disease patients can effectively control motor symptoms and help early stage patients maintain their daily living abilities. Pramipexole combined with levodopa can also effectively improve the ADL score and motor symptom score of patients with advanced Parkinson's disease, and make the life of patients with advanced Parkinson's disease more energetic.
2. Significantly improve the depressive symptoms associated with Parkinson's disease: pramipexole hydrochloride is a dopamine D2, D3 receptor agonist, and the dopamine D3 receptor system may be related to the patient's mood and behavior, pramipexole can selectively Stimulation of D3 receptors, and its agonistic effect on D3 receptors is higher than that of D2 receptors, which can significantly relieve depression symptoms. In a study by Barone et al. in Italy, after Parkinson's disease patients with depression were treated with pramipexole or sertraline, the proportion of patients with depressive symptoms in the pramipexole group was significantly higher than that in the sertraline group. The researchers believe that a dopamine agonist (pramipexole) can replace antidepressants in the treatment of depression in patients with Parkinson's disease. Pramipexole has a protective effect on damaged neurons, and the symptoms of shaking are also well controlled. nerve damage, delay the need for levodopa treatment, reduce the dose of levodopa.

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