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Description of Holo-transferrin from Watson Biotechnology Co., Ltd

Applications of Holo-transferrin CAS11096-37-0 use for Cell Culture and Diagnostic Imaging

Holo-transferrin is the iron-loaded form of transferrin, a glycoprotein that plays a crucial role in the transport and distribution of iron throughout the body. The term "holo" refers to the protein being fully saturated with iron, typically binding two ferric ions (Fe³⁺). The applications of holo-transferrin are diverse, particularly in biomedical research and clinical settings. Here are some key applications:

 1. Cell Culture:

   -*Iron Source: Holo-transferrin is commonly used as a source of iron in cell culture media. Many cell types, especially those that are difficult to culture, require a stable and bioavailable iron source to proliferate and function properly.

   - Serum-Free Media:It is often added to serum-free media formulations to ensure that cells have the necessary iron for various metabolic processes without the need for serum.

 2. Iron Metabolism Studies:

   - Research Tool: Holo-transferrin is used in studies related to iron metabolism, transport, and storage. It helps researchers understand the mechanisms of iron uptake by cells, particularly through transferrin receptors.

   - Receptor Studies: It is utilized to study the expression, regulation, and function of transferrin receptors, which are key players in iron homeostasis.

3. Drug Delivery Systems:

   - Targeted Delivery: Holo-transferrin can be used in the development of drug delivery systems. For example, it can be conjugated to drugs or nanoparticles to target cells that overexpress transferrin receptors, such as certain cancer cells, enhancing the specificity and efficacy of treatments.

   - Cancer Therapy: Because many cancer cells have elevated transferrin receptor levels, holo-transferrin is explored in targeted cancer therapies to deliver cytotoxic agents specifically to tumor cells.

 4.Diagnostic Imaging:

   - Radiolabeling: Holo-transferrin can be radiolabeled and used in imaging techniques, such as positron emission tomography (PET) or magnetic resonance imaging (MRI), to visualize tumors or study iron distribution in the body.

   - Iron Deficiency Anemia: It is used in diagnostic tests to assess iron-binding capacity and transferrin saturation, which are important parameters in the diagnosis of iron deficiency anemia.

 5. Therapeutic Uses:

   - Iron Overload Disorders: While more common with apo-transferrin (the iron-free form), holo-transferrin is also being explored in the treatment of certain iron overload disorders to modulate iron distribution in the body.

   - Neurodegenerative Diseases:It is being investigated for potential therapeutic applications in neurodegenerative diseases where iron dysregulation is implicated, such as Alzheimer's disease or Parkinson's disease.

These applications highlight the versatility of holo-transferrin in both research and clinical contexts, especially in areas related to iron metabolism, targeted therapy, and diagnostics.

Founded in 2006 and headquartered in Wuhan, Hubei, China, Watson Biotechnology Co., Ltd is a leading manufacturing powerhouse specializing in the production of Active Pharmaceutical Ingredients (APIs) and Intermediates, Food and Feed Additives, Agricultural and Aquaculture chemicals, and Fine Chemicals. As a dedicated factory, our operations are driven by a commitment to excellence and innovation, ensuring that our products meet the highest standards of quality and compliance.

With a robust team of over 100 skilled professionals, Watson Biotechnology has established itself as a trusted name in the industry. Our products are meticulously crafted to align with international standards such as USP (United States Pharmacopeia), EP (European Pharmacopoeia), and BP (British Pharmacopoeia), guaranteeing reliability and efficacy.

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