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The cyclopropane motif is an important synthetic unit found in a plethora of natural products and synthetic
bioactive molecules.
Besides, the fluorine atom plays a crucial role in the design and discovery of biologically active compounds.
[1]
Hence, the combination of these two important units, i.e. the fluorine atom or fluorinated group and the
cyclopropyl ring, is of prime importance for the discovery of bioactive molecules.
[2]
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[1] Chem. Rev. 2014, 114, 2432
[2] J. Am. Chem. Soc. 2017, 139, 5293
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Some drugs bearing cyclopropanes substituted by a fluorine atom or a fluorinated group.
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