中文名称
(S)-(+)-Ibuprofen
中文别名
右布洛芬;S-布洛芬;(2S)-2-(4-异丁基苯)丙酸;S-(+)-布洛芬;(S)-(+)-布洛芬;(S)-(+)-2-(4-异丁苯基)丙酸;(S)-(+)-2-(4-Isobutylphenyl)propionic Acid (S)-(+)-2-(4-异丁苯基)丙酸;布洛芬;右旋布洛芬;(+)-布洛芬;2-(4-异丁基苯基)丙酸;(S)-(+)-2-(4-异丁基苯基)丙酸;(S)-(+)-4-异丁基-α-甲基***
英文名称
(S)-(+)-Ibuprofen
英文别名
(S)-2-(4-Isobutylphenyl)propanoic acid;S-(+)-Ibuprofen;(S)-(+)-2-(4-Isobutylphenyl)propionic Acid;(S)-(+)-4-Isobutyl-Alpha-Methylphenylacetic Acid;(S)-(+)-Ibuprofen;(S)-Ibuprofen;Dexibuprofen;(2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid;(2S)-2-[4-(2-Methylpropyl)phenyl]propionic acid;S-(+)-IBU;(S)-(+)-4-Isobutyl-α-methylphenylacetic Acid;S-布洛芬
Cas No.
51146-56-6
分子式
C13H18O2
分子量
206.28
生物活性
(S)-(+)-Ibuprofen ((S)-Ibuprofen), a S(+)-enantiomer of Ibuprofen, is a potent COX-1 and COX-2 inhibitor with IC50s of 2.1 μM and 1.6 μM, respectively. (S)-(+)-Ibuprofen has analgesic, anti-inflammatory, anticancer and antipyretic effects.
性状
Solid
IC50 & Target[1][2]
COX-1
2.1 μM (IC50)
COX-2
1.6 μM (IC50)
体外研究(In Vitro)
(S)-(+)-Ibuprofen (HCT-15 and HCA-7 cells; 0-1000 μM; 8 days) treatment reduces concentration dependently cell survival in both cell lines to a similar extent.
(S)-(+)-Ibuprofen (HCT-15 and HCA-7 cells; 0-1000 μM; 20-72 hours) treatment causes a G0/G1 phase block as well as apoptosis.
(S)-(+)-Ibuprofen (HCT-15 and HCA-7 cells; 900 μM; 4-72 hours) treatment shows a down regulation of cyclin A and B and an increase of the cell cycle inhibitory protein p27Kip-1.
(S)-(+)-Ibuprofen inhibits COX activity, thromboxane formation, and platelet aggregation.
(S)-(+)-Ibuprofen inhibits the activation of NF-κB in response to T-cell stimulation with an IC50 of 61.7 μM.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Proliferation Assay
Cell Line: HCT-15 and HCA-7 cells
Concentration: 0 μM, 200 μM, 400 μM, 600 μM, 700 μM, 800 μM, 900 μM, and 1000 μM
Incubation Time: 8 days
Result: Reduced concentration dependently cell survival in both cell lines to a similar extent.
Cell Cycle Analysis
Cell Line: HCT-15 and HCA-7 cells
Concentration: 0 μM, 200 μM, 400 μM, 600 μM, 800 μM, 900 μM, and 1000 μM
Incubation Time: 24 hours (HCT-15) or 20 hours (HCA-7)
Result: Caused a G0/G1 phase block.
Apoptosis Analysis
Cell Line: HCT-15 and HCA-7 cells
Concentration: 0 μM, 200 μM, 400 μM, 600 μM, 800 μM, 900 μM, and 1000 μM
Incubation Time: 72 hours
Result: Induced cell apoptosis.
Western Blot Analysis
Cell Line: HCT-15 and HCA-7 cells
Concentration: 900 μM
Incubation Time: 4 hours, 8 hours, 16 hours, 24 hours, 32 hours, 48 hours and 72 hours
Result: Decreased levels of Cyclin D1 protein.
体内研究(In Vivo)
(S)-(+)-Ibuprofen (15 mg/kg/day; intraperitoneal injection; five days a week; for 4 weeks) treatment inhibits tumor growth of HCA-7 and HCT-15 xenografts in the nude mice model.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: NMRI (nu/nu) male mice (6-8 week old ) injected with HCA-7 and HCT-15 cells
Dosage: 15 mg/kg/day
Administration: Intraperitoneal injection; five days a week; for 4 weeks
Result: Inhibited tumor growth of HCA-7 and HCT-15 xenografts in mice.
运输条件
Room temperature or refrigerated transportation.
本文来源：https://www.med-life.cn/
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