Camphor ((±)-Camphor) 是一种外用抗感染和抗瘙痒剂,口服有驱风作用。然而,Camphor 摄入时有毒。Camphor 具有抗病毒,镇咳和抗癌活性。
中文名称
[优选]Camphor
中文别名
樟脑;1,7,7-三甲基双环[2.2.1]庚酮-2;合成樟脑;坎酮;莰酮-[2];快状樟脑;天然樟脑;DL-樟脑(试剂);2-莰酮;合成樟脑粉;(±)-樟脑;(+/-)-Camphor (±)-樟脑;(+/-)-樟木;(+/-)-樟脑;(±)-樟脑(合成);DL-樟脑;莪术油;青蒿精油;天然樟脑粉;樟;樟脑 标准品;樟脑(标准品);樟脑(合成);樟脑,天然樟脑粉;樟脑-13C-D3;樟脑粉;樟脑医药级;樟脑原药;2-茨酮;合成;合成樟脑,2-莰酮,樟脑醑,1,7,7-三甲基二环[2.2.1]庚烷-2-酮,柏木精脑;块;天然樟脑粉,树脑;樟脑,合成;樟脑醑;樟脑油;1,7,7-三甲基二环[2.2.1]庚烷-2-酮
英文名称
Camphor
英文别名
Camphor;CAMPHOR SPIRITS;1,7,7-trimethyl-bicyclo(2.2.1)heptan-2-on;1,7,7-trimethylbicyclo[2.2.1]-2-heptanone (camphor);1,7,7-trimethyl-bicyclo[2.2.1]heptan-2-on;1,7,7-trimethyl-norcampho;2-Bornanone;2-Camphanonoe;(+/-)-Camphor;(±)-Camphor;C10H16O;Camphor (dl);Camphor Solution;CAMPHOR, (+/-)-(AS);DL-CAMPHOR, SYNTHETIC, EXTRA PURE BP;Synthetic camphor powder;(±)-bornan-2-one;(1RS,4RS)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one;1,7,7-trimethylbicyclo[2.2.1]heptan-2-one;2-CAMPHOR;2-Kamfanon;Alphanon;Caladryl;camphanone;camphre;DL-CaMphor;Kampfer;lphanon;Radian B;bornan-2-one;1,7,7-Trimethylbicyclo[2.2.1]-2-heptanone;1,7,7-Trimethylnorcamphor;2-Camphanone;[ "" ];l-(-)-Camphor;Root bark oil;Gum camphor;Spirit of camphor;Formosa camphor;Laurel camphor;2-Camphonone;Matricaria camphor;l-Camphor;(-)-Camphor;Camphor, synthetic;Bornane, 2-oxo-;Formosa;Root bark spirit;2-Keto-1,7,7-trimethylnorcamphane;DL-Bornan-2-one;D-(+)-Camphor;Norcamphor, 1,7,7-trimethyl-;Camphor, (1
Cas No.
76-22-2
分子式
C10H16O
分子量
152.23
生物活性
Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities. Camphor is a TRPV3 agonist.
性状
Solid
IC50 & Target[1][2]
TRPV3
体外研究(In Vitro)
Camphor induces fibroblast proliferation through the PI3K/AKT and ERK signaling pathways.
The MTT assay results show that 32.5, 65, 130, and 260 μM Camphor increase fibroblast viability to 108.9±6.6%, 118.6±2.8%, 127.7±4.2%, and 131.6±7.2%, respectively, compared to 0 μM Camphor treatment.
Camphor (0-260 μM) treatment for 24 hours increases the generation of ROS by up to 17.97% compared to 5.04% in the no-treatment control. Camphor (0-260 μM, 24 hours) induces the phosphorylation of PI3K, AKT, ERK, and 4EBP1 in a dose- and time-dependent manner.
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Cell Viability Assay
Cell Line: Primary dermal fibroblast cells
Concentration: 0-260 μM
Incubation Time: 24 hours
Result: 32.5, 65, 130, and 260 μM increased fibroblast viability to 108.9±6.6%, 118.6±2.8%, 127.7±4.2%, and 131.6±7.2%, respectively, compared to 0 μM treatment.
Western Blot Analysis
Cell Line: Primary dermal fibroblast cells
Concentration: 0-260 μM
Incubation Time: 24 hours
Result: Induced the phosphorylation of PI3K, AKT, ERK, and 4EBP1, a repressor of mRNA translation and mTOR substrate, in a dose- and time-dependent manner.
运输条件
Room temperature or refrigerated transportation.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
ClinicalTrial
结构分类
Terpenoids
Other Monoterpenes
来源
Plants
Lauraceae
Cinnamomum camphora
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