Thymidine (NSC 21548, Deoxythymidine, 2'-Deoxythymidine, 5-Methyldeoxyuridine, DThyd)是嘧啶核苷，由连接至糖脱氧核糖的嘧啶碱基胸腺嘧啶组成。作为DNA的组成部分，胸腺嘧啶核苷与DNA双螺旋中的腺嘌呤配对。
中文名称
[优选]Thymidine
中文别名
β-胸腺嘧啶核苷;胸苷;β-胸苷;β-胸苷(dT);2′-脱氧胸苷;2’-脱氧胸苷;2’-脱氧胸苷（胸腺嘧啶核苷）;2'-脱氧胸苷;beta-胸苷;Thymidine 胸苷;β-胸苷 标准品;β-胸苷 技术转让;β-雄苷;齐多夫定相关物质D USP标准品;胸腺嘧啶核苷;胸腺嘧啶脱氧核苷;1-(2-脱氧-β-D-呋喃核糖)-5-甲基尿嘧啶;2′-脱氧胸腺嘧啶核苷;2p-脱氧胸苷;beta-胸甙;Thymidine β-胸苷;β-胸腺嘧啶核苷,2'-脱氧胸腺嘧啶核苷,胸苷,2'-脱氧胸苷,胸腺嘧啶核苷;齐多呋定杂质E(EP) 标准品;去氧胸腺苷;司他呋啶杂质C(EP);脱氧胸苷;胸腺啶;胸腺核苷;胸腺脱氧核苷;1-(2-脱氧-β-D-呋喃核糖)胸苷;2'-脱氧胸腺嘧啶核苷;[ "胸腺嘧啶核苷" ]
英文名称
Thymidine
英文别名
Thymidine;(1-[2-Deoxy-beta-D-ribofuranosyl]-5-methyluracil);2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-erythro-pentofuranosyl)-5-methyl-;2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-ribofuranosyl)-5-methyl-;2'-Deoxythymidine;5-Methyldeoxyuridine;beta-D-Ribofuranoside,thymine-1,2-deoxy-;Deoxythymidine;Dexoythymidine;DThyd;Thymine-2-desoxyriboside;Thyminedeoxyriboside;Uridine,2'-deoxy-5-methyl-;Beta-Thymidine;β-Thymidine;ß-Thymidine;1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydro-furan-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-.β.-D-erythro-pentofuranosyl)-5-methyl-;THYMIDIN(RG);1-(2-Deoxy-β-D-ribofuranosyl)-5-methyluraci;1-(2-Deoxy-β-D-ribofuranosyl)-5-methyluracil;1-(2-Deoxy-β-D-ribofuranosyl)thymine;2,4(1H,3H)-Pyrimidinedione,1-(2-deoxy-.Beta.-D-erythro-pentofuranosyl)-5-methyl;2'-dT;b-Thymidine;DTHD;dT;SS-THYMIDINE;Thymidin;Thymine-2-deoxyriboside;Zidovudine Related Compound D;1-(2-Deoxy-beta-D-ribofuranosyl)-5-methyluracil;1-(2-Deoxy-beta-D-ribofuranosyl)thymine;dT;Thymine deoxyriboside;5-Methyl-2'-deoxyuridine;5-Methyldeoxyurindine;Uridine, 2'-deoxy-5-methyl-;1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione;Deoxyribothymidine;2'-thymidine;beta-D-Ribofuranoside, thymine-1 2-deoxy-
Cas No.
50-89-5
分子式
C10H14N2O5
分子量
242.23
生物活性
Thymidine, a specific precursor of deoxyribonucleic acid, is used as a cell synchronizing agent. Thymidine is a DNA synthesis inhibitor that can arrest cell at G1/S boundary, prior to DNA replication.
性状
Solid
IC50 & Target[1][2]
DNA Synthesis
Human Endogenous Metabolite
Microbial Metabolite
体内研究(In Vivo)
Thymidine (500 mg/kg; i.p.; twice a day) completely reverses both Methotrexate- and Tomudex-induced deletion of both CD4Vβ8 and CD8Vβ8 T cells .
Medlife has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model: 8-12 weeks BALB/c mice
Dosage: 500 mg/kg
Administration: i.p.; twice a day
Result: Completely abrogates Methotrexate- and Tomudex-induced deletion of Vβ8 T cells after SEB injection.
运输条件
Room temperature or refrigerated transportation.
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