武汉佰乐博生物技术有限公司

一、中文名称：

Recombinant HPV18 L1 Major capsid protein L1 Protein, N-GST & C-His，重组HPV18 L1/主要衣壳蛋白L1蛋白，N-GST和C-His，精品重组蛋白

二、产品描述

作为HPV18型衣壳的核心结构蛋白，L1能够自组装形成病毒样颗粒（VLPs），其表面展示的构象依赖性抗原表位可被宿主免疫系统（如B细胞受体和模式识别受体）特异性识别，模拟天然病毒颗粒的免疫原性，从而激活适应性免疫应答，诱导高滴度的型别特异性中和抗体，为HPV预防性疫苗（如多价疫苗）的研发提供关键抗原基础。

三、产品详情

名称：Recombinant HPV18 L1 Major capsid protein L1 Protein, N-GST & C-His，重组HPV18 L1/主要衣壳蛋白L1蛋白，N-GST和C-His，活性蛋白，重组蛋白

货号: YVV11801 

表达系统: E. coli 

种属: Human papillomavirus type 18 

蛋白长度: Val82-Gly535 

预测分子量: 78.56 kDa 

性质: Recombinant 

内毒素水平: Please contact with the lab for this information. 

纯度: >90% as determined by SDS-PAGE. 

Accession号: P06794 

应用: ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress 

状态: Lyophilized 

保存溶液: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. 

重悬: Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. 

运输: In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise. 

稳定性和存储: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt. 

别名: Major capsid protein L1, L1

• 参考文献：

Prospects for cervical cancer prevention by human papillomavirus vaccination. PMID: 17079437

Reducing the economic burden of HPV-related diseases. PMID: 18463361

Methylation of human papillomavirus 16, 18, 31, and 45 L2 and L1 genes and the cellular DAPK gene: Considerations for use as biomarkers of the progression of cervical neoplasia. PMID: 24314662

Methylation of the human papillomavirus-18 L1 gene: a biomarker of neoplastic progression? PMID: 16472835

Comparative Evaluation of Human Papillomavirus Type 16 L1 Protein Expressed in Plasmid- and Baculovirus-Based Systems in Insect Cells. PMID: 32621447

Multivalent human papillomavirus l1 DNA vaccination utilizing electroporation. PMID: 23536912

A method for removing contaminating protein during purification of human papillomavirus type 18 L1 protein from Saccharomyces cerevisiae. PMID: 20162405

详情请咨询Antibodysystem中国授权总代理-武汉佰乐博生物技术有限公司

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