中文名称
5Z,8Z,11Z,14Z-二十碳四烯酸,2-甘油酯; 2-AG; 2-花生四烯酸甘油
英文名字
5Z,8Z,11Z,14Z-eicosatetraenoic acid, 2-glyceryl ester; 2-AG; 2-Arachidonoyl Glycerol
供应商
开曼生物
产品货号
62160-1
产品报价
¥1015.8/1mg
产品说明书
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购买方式
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产品新闻
背景资料
2-Arachidonoyl glycerol (2-AG) is an endogenous agonist of the CB1 receptor. Unlike anandamide, 2-AG is present at relatively high levels in the central nervous system; it is the most abundant molecular species of monoacylglycerol found in rat brain. Formation of 2-AG is calcium-dependent and is mediated by the activities of PLC and DAG lipase. 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3 nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism. 2-AG is metabolized in vitro by MAG lipase and fatty acid amide hydrolase, with MAG lipase likely being the principle metabolizing enzyme in vivo.
产品描述
An analog of arachidonic acid in which the carboxyl group is replaced by a trifluoromethyl ketone group; inhibits the activity of the 85 kDa cPLA2 and the 80 kDa macrophage iPLA2 without altering the activity of the 14 kDa sPLA2s; at a concentration of 7.5 uM, almost completely inhibits hydrolysis of AEA in a rat brain homogenate
保存建议
建议您在收到开曼生物品牌的2-Arachidonoyl Glycerol (1 mg)产品后置于-80度保存,产品有效期为180天.
其他
开曼生物向全球科学工作者提供多研究领域的生化、免疫试剂和分析试剂盒,其产品被广泛应用于肿瘤、氧化氮、神经学、凋亡、氧化性损伤、内分泌学等不同研究领域.开曼生物可提供用于检测的特色试剂盒,如:类花生酸类物质、游离的生物标志、环核苷、激素及氧化氮等;也提供多种高质量试剂,包括:类花生酸类物质、氧化氮试剂及许多相关脂质、脂肪酸、酶和抗体.作为开曼生物在中国的区域总代理,艾美捷科技有限公司将为中国客户提供最全面的开曼生物产品以及客户订制化服务.
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