Name: IMP-1700
CAS#: 1458674-25-3
Chemical Formula: C25H22F4N4O3S
Exact Mass: 534.1349
Molecular Weight: 534.5296
Elemental Analysis: C, 56.18; H, 4.15; F, 14.22; N, 10.48; O, 8.98; S, 6.00
Description: IMP-1700 is an inhibitor of bacterial DNA repair. It potentiates the activity of the quinolone antibiotic ciprofloxacin against methicillin-resistant S. aureus (MRSA) with a combination index value of 0.7. IMP-1700 inhibits the ciprofloxacin-induced bacterial SOS response, a process that repairs DNA damage, in a reporter assay in a concentration-dependent manner. It is also active against E. coli, as well as methicillin-resistant and -sensitive S. aureus, when used alone (EC50s = 0.5, 0.21, and 3.8 µM, respectively).
IUPAC/Chemical Name: 1-Cyclopropyl-6-fluoro-4-oxo-7-[4-[[4-(trifluoromethyl)phenyl]carbamothioyl]piperazin-1-yl]quinoline-3-carboxylic acid
InChi Key: DMUZWIXJZNKJPP-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H22F4N4O3S/c26-19-11-17-20(33(16-5-6-16)13-18(22(17)34)23(35)36)12-21(19)31-7-9-32(10-8-31)24(37)30-15-3-1-14(2-4-15)25(27,28)29/h1-4,11-13,16H,5-10H2,(H,30,37)(H,35,36)
SMILES Code: O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4CCN(C(NC5=CC=C(C(F)(F)F)C=C5)=S)CC4)=C3)C1=O)O
Appearance: Solid powder
关键字： 1458674-25-3;IMP-1700;
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