Name: UJN49930
CAS#: 2414349-93-0
Chemical Formula: C20H22F6N4O4S
Exact Mass: 528.1266
Molecular Weight: 528.4704
Elemental Analysis: C, 45.46; H, 4.20; F, 21.57; N, 10.60; O, 12.11; S, 6.07
Description: UJN49930 is an inhibitor of UDP-galactose ceramide galactosyltransferase (UGT8), also known as ceramide galactosyltranferase (CGT; IC50 = 0.2 nM).1 It is selective for UGT8 over UGT1A1, -1A6, -2B7, -2B15, and -2B17 (IC50s = >10 µM for all). In vivo, UJN49930 inhibits the synthesis of galactosylceramide (GalCer) and sulfatide (SFT) in juvenile mouse brain (ED50s = <3 mg/kg for both) and adult mouse kidney when administered at doses of 3, 10, and 30 mg/kg.
IUPAC/Chemical Name: 1-(3-(methylcarbamoyl)-7-(trifluoromethyl)thieno[3,2-b]pyridin-5-yl)piperidin-4-yl (S)-(1-(trifluoromethoxy)propan-2-yl)carbamate
InChi Key: UQQUABVWYAPTIQ-JTQLQIEISA-N
InChi Code: InChI=1S/C20H22F6N4O4S/c1-10(8-33-20(24,25)26)28-18(32)34-11-3-5-30(6-4-11)14-7-13(19(21,22)23)16-15(29-14)12(9-35-16)17(31)27-2/h7,9-11H,3-6,8H2,1-2H3,(H,27,31)(H,28,32)/t10-/m0/s1
SMILES Code: CNC(C1=CSC2=C(C(F)(F)F)C=C(N3CCC(OC(N[C@H](COC(F)(F)F)C)=O)CC3)N=C12)=O
Appearance: Solid powder
关键字： 2414349-93-0;UJN49930;
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