Name: PF-6422899
CAS#: 1621002-23-0
Chemical Formula: C20H14ClFN4O2
Exact Mass: 396.0789
Molecular Weight: 396.81
Elemental Analysis: \C, 60.54; H, 3.56; Cl, 8.93; F, 4.79; N, 14.12; O, 8.06
Description: PF-6422899 is an irreversible inhibitor of EGFR kinase activity. PF-6422899 binds covalently to active-site cysteine residues in the ATP binding pocket of EGFR.
IUPAC/Chemical Name: N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-(2-propyn-1-yloxy)-6-quinazolinyl]-2-propenamide
InChi Key: AZLXGJFHSLQCPV-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H14ClFN4O2/c1-3-7-28-18-10-16-13(9-17(18)26-19(27)4-2)20(24-11-23-16)25-12-5-6-15(22)14(21)8-12/h1,4-6,8-11H,2,7H2,(H,26,27)(H,23,24,25)
SMILES Code: C=CC(NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1OCC#C)=O
Appearance: Solid powder
关键字: 1621002-23-0;PF-6422899;
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