产品属性：
产品名称 | 规格 | CAS号 | 型号 |
17α-hydroxy Pregnenolone | 100mg 250mg 500mg 1g | 387-79-1 | EY-Y0163814 |
Cas No.387-79-1
别名 NSC 63853
化学名 3β,17-dihydroxy-pregn-5-en-20-one
分子式 C21H32O3
分子量 332.5
溶解度 0.5mg/mL in DMSO
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述：
17α-hydroxy Pregnenolone is a metabolite of pregnenolone and a precursor in the biosynthesis of dehydroepiandrosterone .[1] It is formed from pregnenolone by cytochrome P450 (CYP) isoform CYP17A1 hydroxylase activity and then converted to dehydroepiandrosterone by CYP17A1-mediated 17,20-lyase activity. Plasma levels of 17α-hydroxy pregnenolone are elevated in patients with type II 3β-hydroxysteroid dehydrogenase deficiency, a form of congenital adrenal hyperplasia.[2]
Reference:
[1]. Petrunak, E.M., DeVore, N.M., Porubsky, P.R., et al. Structures of human steroidogenic cytochrome P450 17A1 with substrates. J. Biol. Chem. 289(47), 32952-32964 (2014).
[2]. Fiet, J., Giton, F., Boudi, A., et al. Plasma 17-OH pregnenolone: Comparison of a time-resolved fluoroimmunoassay using a new tracer 17-OH pregnenolone-3-oxyacetyl-biotine with a radioimmunoassay using 125I 17-OH pregnenolone-3-hemisuccinate-histamine. Steroids 66(2), 81-86 (2001).
关键字： 387-79-1;C21H32O3;17α-hydroxy Pregneno;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业，公司自成立以来，秉承""全心全意服务于科研工作者""的企业理念，立足生物科技领域，运用生物技术和科研试剂，发展现代生物科技，为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品，服务生物科技领域的科学研究人员。
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