产品属性:
产品名称 | 规格 | CAS号 | 型号 |
Diprotin A TFA (Ile-Pro-Pro (TFA)) | 5mg 10mM*1mLinWater 25mg 50mg | 209248-71-5 | EY-Y0164679 |
Cas No.209248-71-5
别名 N/A
化学名 N/A
分子式 C19H32F3N3O6
分子量 455.47
溶解度 H2O : ≥ 77.5 mg/mL (170.15 mM)
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述:
Diprotin A (TFA) is an inhibitor of dipeptidyl peptidase IV (DPP-IV).
Diprotin A increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor[1].
In the model of retinopathy of prematurity, Diprotin A increases not only retinal vascularity but also leakage. Additionally, in the murine diabetic retinopathy model, Diprotin A increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway[1].
[1]. Lee CS, et al. Dipeptidyl Peptidase-4 Inhibitor Increases Vascular Leakage in Retina through VE-cadherin Phosphorylation. Sci Rep. 2016 Jul 6;6:29393.
关键字: 209248-71-5;C19H32F3N3O6;Diprotin A TFA (Ile-;
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