DIPROTIN A TFA
中文名称 | DIPROTIN A TFA |
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中文同义词 | 化合物 T11049;抑二肽素 A,三氟乙酸盐 |
英文名称 | Diprotin A TFA (Synonyms: Ile-Pro-Pro (TFA)) |
英文同义词 | Diprotin A TFA (Synonyms: Ile-Pro-Pro (TFA));Diprotin A TFA (Ile-Pro-Pro (TFA));Diprotin A TFA;Ile-Pro-Pro (TFA) |
CAS号 | 209248-71-5 |
分子式 | C19H32F3N3O6 |
分子量 | 455.48 |
EINECS号 | |
相关类别 | |
Mol文件 | 209248-71-5.mol |
结构式 | ![]() |
DIPROTIN A TFA 性质
储存条件 | Store at -20°C |
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形态 | 固体 |
颜色 | 白色至米白色 |
水溶解性 | Water : ≥ 77.5 mg/mL (170.15 mM) |
DPP-IV.
Diprotin A increases the phosphorylation of Src and vascular endothelial-cadherin (VE-cadherin) in human endothelial cells and disrupts endothelial cell-to-cell junctions, which are attenuated by CXCR4 (receptor of SDF-1α)-blocker or Src-inhibitor.
In the model of retinopathy of prematurity, Diprotin A increases not only retinal vascularity but also leakage. Additionally, in the murine diabetic retinopathy model, Diprotin A increases the phosphorylation of Src and VE-cadherin and aggravates vascular leakage in the retinas. Collectively, Diprotin A induces vascular leakage by augmenting the SDF-1α/CXCR4/Src/VE-cadherin signaling pathway.
安全信息
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
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2024/04/30 | HY-111174A | DIPROTIN A TFA Diprotin A TFA | 209248-71-5 | 5mg | 650元 |
2024/04/30 | HY-111174A | DIPROTIN A TFA Diprotin A TFA | 209248-71-5 | 10mM * 1mLin Water | 715元 |