产品属性:
产品名称
规格
CAS号
型号
bpV(phen) (potassium hydrate)
5mg 25mg
171202-16-7
EY-Y0165397
Cas No.171202-16-7
别名 N/A
化学名 N/A
分子式 C12H8N2O5V?K+(H2O)3
分子量 404.3
溶解度 DMSO: 1 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件 Store at -20°C General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. Shipping Condition Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request 产品描述: bpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs), with selectivity for PTEN (IC50 = 38 nM). It also inhibits the vascular endothelial PTP, PTP-β (IC50 = 343 nM), and PTP-1β (IC50 = 920 nM). At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5'-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.
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