产品属性:
产品名称 | 规格 | CAS号 | 型号 |
dBET6 | 10mM*1mLinDMSO 5mg 10mg 25mg 50mg 100mg | 1950634-92-0 | EY-Y0165567 |
Cas No.1950634-92-0
别名 N/A
化学名 N/A
分子式 C42H45ClN8O7S
![dBET6.png dBET6.png](/SupplyImg/2022-11-29/6380533388745672511698165.jpg)
分子量 841.37
溶解度 DMSO : ≥ 100 mg/mL (118.85 mM);H2O : < 0.1 mg/mL (insoluble)
储存条件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述:
dBET6 is a highly potent, selective and cell-permeable degrader of BET based on PROTAC, with an IC50 of 14 nM, and has antitumor activity.
dBET6 is a highly potent, selective and cell-permeable degrader of BET with an IC50 of 14 nM. dBET6 (100 nM) exhibits antitumor activity against T cell acute lymphoblastic leukemia (T-ALL) lines via degradation of BRD4[1].
dBET6 (7.5 mg/kg, p.o., BID) reduces the leukemic burden in a disseminated mouse model of T-ALL[1].
[1]. Winter GE, et al. BET Bromodomain Proteins Function as Master Transcription Elongation Factors Independent of CDK9 Recruitment. Mol Cell. 2017 Jul 6;67(1):5-18.e19.
关键字: 1950634-92-0;C42H45ClN8O7S;dBET6;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要从事免疫学、分子生物学和常规生化试剂等为一体的科研产品销售企业,公司自成立以来,秉承""全心全意服务于科研工作者""的企业理念,立足生物科技领域,运用生物技术和科研试剂,发展现代生物科技,为各类大中小医院及其它医疗机构、高等院校、科研院所、企事业单位提供优质的产品,服务生物科技领域的科学研究人员。
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