别名
2-[(3-Aminopropyl)amino]ethanethiol dihydrochloride,WR-1065 dihydrochloride
生化/生理作用
WR-1065 is cytoprotective cell-permeable reactive oxygen species scavenger and p53 activator and re-activator. Recently shown to have antiretroviral activity and an active metabolite of Amifostine which selectively protects normal tissues from the damaging effects of anti-neoplastic radiation therapy. WR-1065 is the active metabolite of the prodrug amifostine, generated by alkaline phosphatase. It is found to accumulate in many epithelial tissues. WR-1065 protects cellular membranes and DNA from free radical induced damage.
Sigma-Aldrich西格玛奥德里奇(上海)贸易有限公司
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