Product Name：PMX-53
CAS No.：219639-75-5
Synonyms：3D53；拮抗剂多肽PMX-53
Catalog No.：217P616
Brand：HongTide（上海鸿肽生物）
Description：PMX-53(3D53)是一种合成肽，也是一种有效的，具有口服活性的补体C5a受体(CD88)拮抗剂多肽，序列中含有3个非天然氨基酸，并且有一个环状结构，IC50为20nM。PMX-53还是一种低亲和力的MrgX2激动剂，可刺激MrgX2介导的肥大细胞脱颗粒。PMX-53特异性结合C5aR1，不结合第二个C5aR(C5L2)和C3aR。PMX-53具有抗炎，抗癌和抗动脉粥样硬化作用。
PMX-53 (3D53) is a synthetic peptide and an effective complement C5a receptor (CD88) antagonist peptide with oral activity. The sequence contains three unnatural amino acids and has a circular structure with an IC50 of 20 nM. PMX-53 is also a low affinity MrgX2 agonist that can stimulate MrgX2 mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anti-cancer and anti atherosclerosis effects.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | Ac-F-cyclo(Orn-P-D-Cha-WR) |
Sequence(3-letter code) | Ac-Phe-cyclo(Orn-Pro-D-Cha-Trp-Arg) |
Peptide Structure | 
|
Molecular Formula | C47H65O7N11 |
Molecular Weight | 896.09 |
订购联系方式：
上海鸿肽生物科技有限公司
手机： +86-18018095145 （同微信号）
QQ: 3259098395
邮箱：sales1@hongtide.com
关键字： 219639-75-5;PMX-53;拮抗剂多肽PMX-53;多肽;多肽合成;
上海鸿肽生物科技有限公司（简称：鸿肽生物）是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖：定制多肽、目录多肽、氨基酸衍生物、小分子化合物；公司自成立以来，秉持“用质量作船， 以服务为帆，为科研服务”的企业理念，为国内外众多科研工作者提供了优质的服务及产品。