Product Name:Nogo-66 (1-40)
CAS No.:475221-20-6
Synonyms:抑制剂多肽Nogo-66 (1-40)
Catalog No.:218P071
Brand:HongTide(上海鸿肽生物)
Description:Nogo-66 (1-40)是对应于Nogo-66的残基1-40的多肽,序列中含有40个氨基酸,肽链两端均被封闭,Nogo-66是抑制轴突生长的髓鞘蛋白Nogo的结构域。作为Nogo-66受体(NgR)的竞争性拮抗剂,能阻断Nogo-66和CNS髓鞘诱导的轴突生长抑制,但在体外不降低髓鞘相关糖蛋白(MAG)对轴突生长的抑制。Nogo-66 (1-40)在体内脊髓损伤后促进半切脊髓轴突的再生和运动恢复。
"Nogo-66 (1-40) is a peptide corresponding to residues 1-40 of Nogo-66. The sequence contains 40 amino acids, and both ends of the peptide chain are blocked. Nogo-66 is the domain of the myelin protein Nogo, which inhibits axon growth.". As a competitive antagonist of the Nogo-66 receptor (NgR), it can block the inhibition of axon growth induced by the myelin sheath of Nogo-66 and CNS, but does not reduce the inhibition of myelin associated glycoprotein (MAG) on axon growth in vitro. Nogo-66 (1-40) promotes axonal regeneration and motor recovery after spinal cord injury in vivo.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility:H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | Ac-RIYKGVIQAIQKSDEGHPFRAYLESEVAISEELVQKYSNS-NH2 |
Sequence(3-letter code) | Ac-Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH2 |
Peptide Structure | ![Nogo-66 (1-40) 475221-20-6.png Nogo-66 (1-40) 475221-20-6.png](/SupplyImg/2023-03-27/6381554877318729981725221.jpg)
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Molecular Formula | C206H324N56O65 |
Molecular Weight | 4625.18 |
订购联系方式:
上海鸿肽生物科技有限公司
手机: +86-18018095145 (同微信号)
QQ: 3259098395
邮箱:sales1@hongtide.com
关键字: 475221-20-6;Nogo-66 (1-40);抑制剂多肽Nogo-66 (1-40);多肽;多肽合成;
上海鸿肽生物科技有限公司(简称:鸿肽生物)是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖:定制多肽、目录多肽、氨基酸衍生物、小分子化合物;公司自成立以来,秉持“用质量作船, 以服务为帆,为科研服务”的企业理念,为国内外众多科研工作者提供了优质的服务及产品。