Rabbit Anti-PRSS10 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:PRSS10
IR:Immunogen Range:301-400/492
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:7113
Swiss Prot:O15393
Source:KLH conjugated synthetic peptide derived from human PRSS10:301-400/492
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors (1,2). The TMPRSS2 gene encodes a 492 amino acid multimeric serine protease, which is mainly expressed in the mouse prostate and kidney, and is also expressed in the human small intestine, prostate, colon, stomach and salivary gland (3,4). TMPRSS2 contains several domains, including a serine protease domain of the S1 family, a scavenger receptor cysteine-rich domain of group A, an LDL receptor class A domain and a transmembrane domain (3). TMPRSS2 is expressed as a full length form and a cleaved protease domain (5) and its expression is increased by androgenic hormones. TMPRSS2 is also expressed in prostate carcinoma, suggesting that it may play a role in prostate carcinogenesis (6).
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
Flow-Cyt(2ug/Test)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Pig
Cow
Sheep
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： PRSS10;Epitheliasin;Serine protease 10;TMPRSS2;TMPRSS2 ETV1;Transmembrane;D16Ertd61e;TMPS2_HUMAN;
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