Rabbit Anti-Sprouty1 Polyclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Sprouty1
IR:Immunogen Range:221-319/319
Clonality:Polyclonal
Isotype:IgG
Entrez Gene:10252
Swiss Prot:O43609
Source:KLH conjugated synthetic peptide derived from human Sprouty1:221-319/319
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:Members of the Sprouty family (Sprouty 1-4) are inducible negative regulators of growth factors that act through tyrosine kinase receptors. Mammalian Sprouty homologs share a well-conserved cysteine-rich C-terminal domain with their Drosophila counterparts. Both Sprouty 1 and 2 are anchored to membranes by palmitoylation, associate with caveolin-1 in perinuclear and vesicular structures and are phosphorylated on Serine residues. Upon stimulation, a subset is recruited to the leading edge of the plasma membrane. Sprouty 2 can associate with c-Cbl, a down regulator of RTK signaling, and inhibits the activities of several growth factors. Sprouty 2 also functions as a negative regulator of embryonic lung morphogenesis and growth. The well-conserved C-terminus of Sprouty contains two domains which are necessary for Sprouty 2 co-localization with microtubules and translocation to membrane ruffles. In addition, the C-terminus is required for the inhibition of cell migration and proliferation. In conclusion, members of Sprouty inhibit FGF and VEGF-mediated cell proliferation, suggesting that they may regulate angiogenesis in normal and disease processes.
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
ELISA(1:5000-10000)
IHC-P(1:100-500)
IHC-F(1:100-500)
ICC(1:100-500)
IF(1:100-500)
Cross Reactive Species:Human
Mouse
Rat
Chicken
Dog
Pig
Cow
Horse
![image.png image.png](/SupplyImg/2023-08-02/6382656533591522633436627.jpg)
仅供科研使用。不能用于人和动物治疗等其它临床诊断用!
关键字: Sprouty1;Sprouty 1;hSPRY1;Protein sprouty homo;Sprouty homolog 1 ;Spry1;软脂酰化磷蛋白Sprouty1抗体;SPY1_HUMAN;
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