Rabbit Anti-Bcl-2 Monoclonal Antibody
DATASHEET
Host:Rabbit
Target Protein:Bcl-2
IR:Immunogen Range:
Clonality:Monoclonal
Isotype:IgG
Entrez Gene:596
Swiss Prot:P49950
Source:KLH conjugated synthetic peptide derived from human Bcl-2:
Purification:affinity purified by Protein A
Storage:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Background:The Bcl-2 gene was isolated at the chromosomal breakpoint of t(14;18)-bearing follicular B cell lymphomas(1,2).Bcl-2 blocks cell death following a variety of stimuli and confers a death-sparing effect to certain hematopoietic cell lines following growth factor withdrawal (3,5).Bcl-2 appears to function in several subcellular locations yet lacks any known motifs that would confer insight into its mechanism of action (6,7).A more recently identified protein,designated Bax p21(i.e., Bcl-associated X protein ),has extensive amino acid homology with Bcl-2 and both homodimerizes and forms heterodimers with Bcl-2(8). Overexpression of Bax accelerates apoptotic death induced by cytokine deprivation in an IL-3 dependent cell line and Bax also counters the death repressor activty of Bcl-2(8).
Size:50ul
Concentration:1mg/ml
Applications:WB(1:500-2000)
IP(1:10-50)
IHC-P(1:100-500)
IHC-F(1:50-200)
Flow-Cyt(1ug/Test)
IF(1:50-200)
Cross Reactive Species:Human
Mouse
仅供科研使用。不能用于人和动物治疗等其它临床诊断用！
关键字： Bcl-2;Apoptosis regulator ;Apoptosis regulator ;AW986256; B cell CLL/lymphoma;Bcl2;BCL2 protein;BCL2_HUMAN;
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