Product Name:ProTx II
CAS No.:484598-36-9
Synonyms:选择性阻滞剂多肽ProTx II
Catalog No.:218P444
Brand:HongTide(上海鸿肽生物)
Description:ProTx II一种Nav1.7 钠通道的选择性阻滞剂多肽,序列中含有30个氨基酸,并且包含三对二硫键,IC50 值为 0.3 nM,对 Nav1. 7的选择性是其他钠通道亚型的至少 100 倍。ProTx-II 通过降低通道电导和将激活的电压转移到更多的正电位来抑制钠离子通道,并阻止伤害感受器中动作电位的传播。
ProTx II is a selective blocking peptide of Nav1.7 sodium channel, which contains 30 amino acids in its sequence and three pairs of disulfide bonds. Its IC50 value is 0.3 nM, which affects Nav1 The selectivity of 7 is at least 100 times that of other sodium channel subtypes. ProTx-II suppresses sodium ion channels and prevents the propagation of action potentials in nociceptors by reducing channel conductivity and transferring activated voltage to more positive potentials.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility:H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | YCQKWMWTCDSERKCCEGMVCRLWCKKKLW(Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys25) |
Sequence(3-letter code) | H-Tyr-Cys-Gln-Lys-Trp-Met-Trp-Thr-Cys-Asp-Ser-Glu-Arg-Lys-Cys-Cys-Glu-Gly-Met-Val-Cys-Arg-Leu-Trp-Cys-Lys-Lys-Lys-Leu-Trp-OH(Disulfide bridge:Cys2-Cys16;Cys9-Cys21;Cys15-Cys25) |
Peptide Structure | ![ProTx II 484598-36-9.png ProTx II 484598-36-9.png](/SupplyImg/2023-08-13/6382756290993343175574827.jpg)
|
Molecular Formula | C168H250N46O41S8 |
Molecular Weight | 3826.59 |
订购联系方式:
上海鸿肽生物科技有限公司
手机: +86-18018095145 (同微信号)
QQ: 3259098395
邮箱:sales1@hongtide.com
关键字: 484598-36-9;ProTx II ;选择性阻滞剂多肽ProTx II;多肽;多肽合成;
上海鸿肽生物科技有限公司(简称:鸿肽生物)是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖:定制多肽、目录多肽、氨基酸衍生物、小分子化合物;公司自成立以来,秉持“用质量作船, 以服务为帆,为科研服务”的企业理念,为国内外众多科研工作者提供了优质的服务及产品。