中文名:SB-203580,p38 MAPK抑制剂
英文名:SB-203580
英文别名:152121-47-6|SB 203580|SB-203580|SB203580|4-(4-Fluorophenyl)-2-(4-methylsulfinylphenyl)-5-(4-pyridyl)-1H-imidazole|Adezmapimod|4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine|4-(4-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-1H-
纯度:≥98%(HPLC)
货号:S131899
包装:100mg、5mg、25mg
Cas号:152121-47-6
存储温度:-20°C储存
产品介绍:
SB203580是一种p38 MAPK抑制剂,在THP-1细胞中IC50为0.3-0.5 μM,对SAPK3(106T)和SAPK4(106T)选择性低10倍,且阻断PKB磷酸化,IC50为3-5 μMMDCK cells were treated with SB 203580 to study the role of MAPK signaling in inducing hypertonicity of cell membrane and potassium depletion.16 It was used to inhibit MAPK signaling in mouse cortical neurons17 and human hepatocellular carcinoma cell lines.18
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