中文名:LF3
英文名:LF3
英文别名:1-Piperazinecarbothioamide,N-[4-(aminosulfonyl)phenyl]-4-(3-phenyl-2-propen-1-yl)-
纯度:98%
货号:L414020
包装:10mg、50mg、100mg
Cas号:664969-54-4
存储温度:-20°C储存
产品介绍:
Information
LF3 LF3 is a specific inhibitor of canonical Wnt signaling by disrupting the interaction between β-catenin and TCF4 with an IC50 less than 2 μM.
Targets
β-catenin/Tcf4 (Cell-free assay) 1.65 μM
In vitro
LF3 does not cause cell death or interfere with cadherin-mediated cell-cell adhesion. The self-renewal capacity of cancer stem cells is blocked by LF3 in concentration-dependent manners, as examined by sphere formation of colon and head and neck cancer stem cells under nonadherent conditions. LF3 inhibits Wnt/β-catenin signaling, but does not interfere with E-cadherin/β-catenin-mediated cell-cell adhesion. LF3 blocks the expression of a series of Wnt target genes in Wnt-addicted colon cancer cells. It inhibits proliferation of Wnt-addicted colon cancer cells through induction of cell-cycle arrest and also inhibits self-renewal capacity of CSCs.
In vivo
LF3 reduces tumor growth and induces differentiation in a mouse xenograft model of colon cancer while exhibiting no significant toxicity for mice and does not disturb the normal histology of the gut of mice.
Cell Research(from reference)
Cell lines:The cell lines HCT116, HCT15, HT29, SW480, SW620, LS174T, SW48, MCF7, HeLa, HEK293, and MDCK\xa0
Concentrations:3.3-60 μmol/L
Incubation Time:24 h
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关键字: 1-?Piperazinecarbothioa?mide,N-?[4-?(aminosulfonyl)?phenyl]?-?4-?(3-?phenyl-?2-?propen-?1-?yl)?-
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