Product Name：Pancreatic Polypeptide,human
CAS No.：75976-10-2；59763-91-6
Synonyms：胰腺分泌多肽
Catalog No.：193P02
Brand：HongTide（上海鸿肽生物）
Description：Pancreatic Polypeptide, human 是一种 C 端酰胺化的36个氨基酸肽，可作为神经肽 Y (NPY) Y4/Y5 受体激动剂。人胰多肽 (hPP) 就是这样一种肽，餐后根据热量负荷、食物消耗和昼夜节律从胰岛的 F 细胞中释放出来。 它是一种 C 端酰胺化的 36 个氨基酸肽，具有特征性的发夹样胰腺多肽 (PP) 折叠，作用于 Y4 受体以诱导饱腹感并延迟胃排空和运动。 添加人胰腺多肽 (hPP) (10 nM-1 μM) 导致基础释放和受激释放显着的剂量依赖性降低。 人胰多肽 (hPP) 还可以抑制基础和刺激的 NPY 释放，其药理学特征表明 Y4 突触前受体的作用。
Pancreatic Polypeptide, human, is a C-terminal amidated 36 amino acid peptide that can serve as a neuropeptide Y (NPY) Y4/Y5 receptor agonist. Human pancreatic peptide (hPP) is such a peptide that is released from the F cells of the pancreas after meals based on calorie load, food consumption, and circadian rhythm. It is a C-terminal amidated 36 amino acid peptide with characteristic hairpin like pancreatic peptide (PP) folding that acts on the Y4 receptor to induce satiety and delay gastric emptying and movement. Adding human pancreatic peptide (hPP) (10 nM-1) μ M) Resulting in a significant dose-dependent decrease in basal and stimulated release. Human pancreatic peptide (hPP) can also inhibit the release of basal and stimulated NPY, and its pharmacological characteristics indicate the role of Y4 presynaptic receptors.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY-NH2 |
Sequence(3-letter code) | H-Ala-Pro-Leu-Glu-Pro-Val-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Gln-Tyr-Ala-Ala-Asp-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Leu-Thr-Arg-Pro-Arg-Tyr-NH2 |
Peptide Structure | 
|
Molecular Formula | C185H287N53O54S2 |
Molecular Weight | 4181.8 |
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上海鸿肽生物科技有限公司
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本产品仅供科研使用。
关键字： Pancreatic Polypepti;59763-91-6;75976-10-2;胰腺分泌多肽;多肽;
上海鸿肽生物科技有限公司（简称：鸿肽生物）是一家以多肽以及多肽上下游产品研发、生产、销售以及技术转让为主要业 务科技公司。公司现有产品涵盖：定制多肽、目录多肽、氨基酸衍生物、小分子化合物；公司自成立以来，秉持“用质量作船， 以服务为帆，为科研服务”的企业理念，为国内外众多科研工作者提供了优质的服务及产品。