| 中文名 | 盐酸替莫普利
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| 英文名 | Temocapril hydrochloride
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| 别名 | 盐酸替莫普利
替莫普利盐酸盐
盐酸替莫普利及中间体
TEMOCAPRIL HYDROCHLORIDE盐
[(2S,6R)-6-[[(S)-1-(乙氧羰基)-3-苯基丙基]氨基]-5-氧代-2-(2-噻吩基)-1,4-硫氮杂卓-4-基]乙酸盐酸盐
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| 英文别名 | CS-622
Acecol
TemocarpileHCL
Temocapril Hcl
Temocarpilhydrochloride
Temocapril hydrochloride
TEMOCAPRIL HYDROCHLORIDE
Temocapril HCl and intermediates
[(2S,6R)-6-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-5-oxo-2-(thiophen-2-yl)-1,4-thiazepan-4-yl]acetic acid
(2S,6R)-6-[[(1S)-1-(Ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-1,4-thiazepine-4(5H)-acetic Acid Hydrochloride
1,4-Thiazepine-4(5H)-acetic acid, 6-[[1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, [2S-[2a,6b(R*)]]-
1,4-Thiazepine-4(5H)-acetic acid, 6-[[(1S)-1-(ethoxycarbonyl)-3-phenylpropyl]amino]tetrahydro-5-oxo-2-(2-thienyl)-, monohydrochloride, (2S,6R)- (9CI)
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| CAS | 110221-44-8
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| EINECS | 1312995-182-4 |
| 化学式 | C23H28N2O5S2.ClH
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| 分子量 | 513.076 |
| InChI | InChI=1/C23H28N2O5S2/c1-2-30-23(29)17(11-10-16-7-4-3-5-8-16)24-18-15-32-20(19-9-6-12-31-19)13-25(22(18)28)14-21(26)27/h3-9,12,17-18,20,24H,2,10-11,13-15H2,1H3,(H,26,27)/t17-,18-,20-/m0/s1 |
| 密度 | 1.33g/cm3 |
| 熔点 | 196-2000C (dec) |
| 沸点 | 717.4°C at 760 mmHg |
| 比旋光度 | 25D +47.7° (c = 1 in DMF) |
| 闪点 | 387.7°C |
| 蒸汽压 | 1.34E-21mmHg at 25°C |
| 溶解度 | DMF (微溶) 、DMSO (微溶) 、甲醇 (微溶) |
| 折射率 | 1.628 |
| 存储条件 | Inert atmosphere,Store in freezer, under -20°C |
| 外观 | 固体 |
| 颜色 | White to Off-White |
| 体外研究 | Temocapril hydrochloride is a prodrug of the ACE inhibitor, Temocaprilat. Temocapril hydrochloride can be readily uptaken via the human small intestine, and then be converted to its active metabolite (temocaprilat) by CES1 in the liver. |
| 体内研究 | Temocapril hydrochloride (30 mg/kg; p.o.; daily; for 4 weeks) suppresses Angiotensin I-induced hypertension, plasma and renal ACE activity, but fails to reduce the level of Ang II in the kidney. Animal Model: Male Sprague Dawley rats Dosage: 30 mg/kg Administration: Oral administration, daily, for 4 weeks Result: Suppressed the blood pressure elevation induced by Ang I. |
| 危险品标志 | Xi - 刺激性物品
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| 风险术语 | 36/37/38 - 刺激眼睛、呼吸系统和皮肤。
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| 安全术语 | S26 - 不慎与眼睛接触后，请立即用大量清水冲洗并征求医生意见。
S36 - 穿戴适当的防护服。 |