CD206产品信息
英文名称:Macrophage mannose receptor 1
中文名称:巨噬细胞甘露糖受体-1
靶点别称:MMR,CD206,hMR,MRC1,CLEC13D,CLEC13DL,MRC1L1
物种:Human/Mouse
属性:Protein
标记:Biotin-labeled/Unconjugated
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
CD206分子背景
Mrc1是一种保守的检查点介导蛋白,它将复制应激信号转导给下游效应激酶。Mrc1及其脊椎动物同源物Claspin充当复制应激检查点信号传导的介质,从Mec1/Rad3/ATR传感器激酶接收信号并将其传递给效应器Rad53/Cds1/Chk1激酶。mrc1检查点活性的丧失导致羟基脲存在时晚期/休眠起源的异常激活。表达多配体内吞受体甘露糖受体(CD206/MRC1)的肿瘤相关巨噬细胞(TAM)有助于肿瘤免疫抑制、血管生成、转移和复发。
关键字: CD206;CD206蛋白;MMR;MMR蛋白;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。