Flt-3产品信息
英文名称:Tyrosine-protein kinase receptor FLT3
中文名称:酪氨酸蛋白激酶受体FLT3
靶点别称:Flt-3,Flk-2,STK-1,CD135,FLK2,FLT-3
物种:Human/Mouse/Cynomolgus
属性:Protein
标记:Biotin-labeled/FITC Labeled/Unconjugated
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
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Flt-3用户评价
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Flt-3分子背景
Flt-3(受体型酪氨酸蛋白激酶FLT3)也被称为FLK-2(胎儿肝激酶-2)、STK-1(干细胞酪氨酸激酶1)、CD135。FLT3是一种细胞因子受体,属于受体酪氨酸激酶III类。酪氨酸蛋白激酶作为细胞因子FLT3LG的细胞表面受体,调节造血祖细胞和树突状细胞的分化、增殖和存活。促进SHC1和AKT1的磷酸化,以及下游效应子MTOR的激活。促进RAS信号传导的激活和下游激酶的磷酸化,包括MAPK1/ERK2和/或MAPK3/ERK1。引起组成型激酶活性的突变通过激活多种信号通路促进细胞增殖和抗凋亡。
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关键字: Flt-3;Flt-3蛋白;CD135;CD135蛋白;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。