Human TGF-Beta 1 / TGFB1 Protein, Tag Free
分子别名(Synonym)
CEDLAP,TGF-beta 1,TGFB1,DPD1,TGF-beta-1,TGFB
表达区间及表达系统(Source)
Human TGF-Beta 1 Protein, Tag Free (TG1-H4212) is expressed from human 293 cells (HEK293). It contains AA Ala 279 - Ser 390 (Accession # P01137-1).
Predicted N-terminus: Ala 279
蛋白结构(Molecular Characterization)
This protein carries no "tag".
The protein has a calculated MW of 12.8 kDa (monomer). The protein migrates as 14 kDa (monomer) under reducing (R) condition, and 25 kDa (Dimer) when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE).
内毒素(Endotoxin)
Less than 0.1 EU per μg by the LAL method.
宿主蛋白残留(Host Cell Protein)
<0.5 ng/µg of protein tested by ELISA.
宿主核酸残留(Host Cell DNA)
<0.02 ng/μg of protein tested by qPCR.
无菌(Sterility)
Negative
支原体(Mycoplasma)
Negative.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in 0.085% TFA in 30% ACN with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 12 months under sterile conditions after reconstitution.
背景(Background)
转化生长因子β1(TGFB1)也称为TGF-β1,CED,DPD1,TGFB。是细胞因子转化生长因子β超家族的多肽成员。它是一种分泌蛋白,具有许多细胞功能,包括控制细胞生长,细胞增殖,细胞分化和凋亡。TGFB1蛋白有助于控制细胞的生长和分裂(增殖),细胞成熟以执行特定功能(分化),细胞运动(运动)和细胞自我破坏(凋亡)的过程。TGFB1蛋白遍布全身,在出生前的发育,血管的形成,肌肉组织和体脂发育的调节,伤口愈合和免疫系统功能中起作用。TGFB1在构成骨骼的组织中特别丰富,它有助于调节骨骼的生长,并且在细胞之间的空间(细胞外基质)中形成复杂的晶格。在细胞内,这种蛋白质被关闭(无活性),直到它接收到化学信号变得活跃。TGFB1在控制免疫系统中起着重要作用,并且在不同类型的细胞或处于不同发育阶段的细胞上显示出不同的活性。大多数免疫细胞(或白细胞)分泌TGFB1。已显示TGFB1与TGFβ受体1,LTBP1,YWHAE,EIF3I和核心蛋白聚糖相互作用。
关键字: TGF-Beta 1;TGF-Beta 1蛋白;TGF-Beta 1重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。