Human DR3 Protein, Fc Tag (MALS verified)
分子别名(Synonym)
TNFRSF25,DR3,APO3,DDR3,TNFRSF12,WSL,WSL1
表达区间及表达系统(Source)
Human DR3 Protein, Fc Tag (DR3-H5253) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Gln 199 (Accession # Q93038-1).
蛋白结构(Molecular Characterization)
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 45.5 kDa. The protein migrates as 53-63 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
肿瘤坏死因子受体超家族成员25(TNFRSF25)也称为Apo-3、死亡受体3(DDR3或DR3)、细胞凋亡诱导受体AIR、细胞凋亡介导受体TRAMP、淋巴细胞相关死亡受体Apo-3,是TNF受体超家族的成员。TNFRSF25是一种同源二聚体蛋白,它可以通过死亡结构域与TNFRSF1和TRADD强烈相互作用,激活至少两种不同的信号级联,即凋亡和NF-kappa-B信号。TNFRSF25是TNFSF12/APO3L/TWEAK的受体。
关键字: DR3;DR3蛋白;DR3重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。