Human CD47 Protein, His Tag (MALS verified)
分子别名(Synonym)
CD47,MER6,IAP,OA3
表达区间及表达系统(Source)
Human CD47, His Tag (CD7-H5227) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Pro 139 (Accession # Q08722-3).
Predicted N-terminus: Gln 19
蛋白结构(Molecular Characterization)
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This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 15.6 kDa. The protein migrates as 33-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 24 months in lyophilized state;
-70°C for 12 months under sterile conditions after reconstitution.
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背景(Background)
白细胞表面抗原CD47也被称为抗原表面决定蛋白OA3、整合素相关蛋白(IAP)和蛋白MER6。CD47含有1个Ig样V型(免疫球蛋白样)结构域。CD47在正常成人组织中分布非常广泛。CD47通过充当血小板上THBS1的粘附受体在细胞粘附中发挥作用,并在整合素的调节中发挥作用。通过相似性,CD47在海马的记忆形成和突触可塑性中起着重要作用。CD47是SIRPA的受体,与SIRPA结合可阻止未成熟树突状细胞的成熟,并抑制成熟树突状细胞产生细胞因子。CD47与SIRPG的相互作用介导细胞间粘附,增强超抗原依赖性T细胞介导的增殖,并共刺激T细胞活化。
关键字: CD47;CD47蛋白;CD47重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。