Human LRRC15 / LIB Protein, His Tag (MALS verified)
分子别名(Synonym)
Leucine-rich repeat-containing protein 15,LRRC15,LIB,hLib
表达区间及表达系统(Source)
Human LRRC15, His Tag (LR5-H52H3) is expressed from human 293 cells (HEK293). It contains AA Tyr 22 - Gly 538 (Accession # Q8TF66-1).
Predicted N-terminus: Tyr 22
蛋白结构(Molecular Characterization)
![1.jpg 1.jpg](/SupplyImg1/2024-07-18/6385689767830246337109760.jpg)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 59.8 kDa. The protein migrates as 70-90 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
![2.jpg 2.jpg](/SupplyImg1/2024-07-18/6385689768823416922621506.jpg)
背景(Background)
LRRC15(富含亮氨酸重复序列的蛋白质15)也被称为LIB和hLib。LRRC15在多种实体瘤中高度表达。LRRC15在许多实体瘤(如乳腺、头颈部、肺、胰腺)的基质成纤维细胞上表达,也直接在间充质来源的癌症细胞亚群(如肉瘤、黑色素瘤、胶质母细胞瘤)上表达。TGFβ诱导活化的成纤维细胞(α-SMA+)和间充质干细胞表达LRRC15。这些集体发现表明,LRRC15是一种新型的CAF和间充质标志物,可作为治疗LRRC15阳性间质促纤维增生症或间充质来源癌症的治疗靶点。ABBV-085是一种针对LRRC15的含单甲基金抑制素E(MMAE)的抗体-药物偶联物(ADC),它作为单一疗法或与标准护理疗法相结合,对LRRC15中的异常阳性/癌症阴性和LRRC15癌症阳性模型表现出强大的临床前疗效。
关键字: LRRC15;LRRC15蛋白;LRRC15重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。