Human IL-5 Protein, His Tag
分子别名(Synonym)
IL-5,TRF,IL5,Interleukin-5
表达区间及表达系统(Source)
Human IL-5 Protein, His Tag (IL5-H52H3) is expressed from human 293 cells (HEK293). It contains AA Ile 20 - Ser 134 (Accession # P05113-1).
Predicted N-terminus: His
蛋白结构(Molecular Characterization)
![1.jpg 1.jpg](/SupplyImg1/2024-07-31/6385804310558362222133431.jpg)
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 15.0 kDa. The protein migrates as 18-23 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 0.1 EU per μg by the LAL method.
无菌(Sterility)
Negative
支原体(Mycoplasma)
Negative.
纯度(Purity)
>90% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
![2.jpg 2.jpg](/SupplyImg1/2024-07-31/6385804311255641069171562.jpg)
![3.jpg 3.jpg](/SupplyImg1/2024-07-31/6385804311507431504590310.jpg)
背景(Background)
白细胞介素5(IL-5)是由2型T辅助细胞和肥大细胞产生的白细胞介蛋白。IL-5是一种长115个氨基酸(在人类中为133个氨基酸)的TH2细胞因子,是造血家族的一部分。与该细胞因子家族的其他成员(即白细胞介素3和GM-CSF)不同,这种活性形式的糖蛋白是同二聚体。白细胞介素-5长期以来与包括过敏性鼻炎和哮喘在内的几种过敏性疾病的病因有关,其中观察到循环、气道组织和诱导痰嗜酸性粒细胞的数量大幅增加。鉴于嗜酸性粒细胞的高度一致性,特别是过敏性哮喘的病理学,人们普遍推测嗜酸性粒血球在这种疾病的病理学中起着重要作用。靶向IL-5的药物是美珠单抗和瑞珠单抗。
关键字: IL-5;IL-5蛋白;IL-5重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。