Human uPAR / PLAUR Protein, His Tag (MALS verified)
分子别名(Synonym)
uPAR,PLAUR,CD87,MO3
表达区间及表达系统(Source)
Human uPAR, His Tag (UPR-H5226) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Arg 303 (Accession # AAH02788).
Predicted N-terminus: Leu 23
蛋白结构(Molecular Characterization)
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This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 32.3 kDa. The protein migrates as 40-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>92% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
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背景(Background)
尿激酶纤溶酶原激活物表面受体(U-PAR)也称为PLAUR、单核细胞激活抗原Mo3、CD抗原CD87。PLAUR包含三个UPAR/Ly6结构域。U-PAR在大脑外侧区的神经元中表达(在蛋白质水平上),也在大脑中表达。PLAUR/CD87与MRC2、SRPX2和SORL1相互作用。PLAUR/UPAR作为尿激酶型纤溶酶原激活物的受体,在定位和促进纤溶酶形成方面发挥作用。U-PAR介导U-PA的蛋白水解非依赖性信号转导激活效应。
关键字: uPAR;uPAR蛋白;uPAR重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。