NOTCH2产品信息
英文名称:Neurogenic locus notch homolog protein 2
中文名称:神经源性基因座notch同源蛋白-2
靶点别称:NOTCH2
物种:Human
标签:Fc Tag
属性:Protein
标记:Unconjugated
表达区间及表达系统(Source)
Human NOTCH2, Fc Tag (NO2-H5255) is expressed from human 293 cells (HEK293). It contains AA Leu 26 - Gln 530 (Accession # Q04721-1).
Predicted N-terminus: Leu 26
蛋白结构(Molecular Characterization)
This protein carries a human IgG1 Fc tag at the C-terminus.
The protein has a calculated MW of 80.5 kDa. The protein migrates as 90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
内毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
纯度(Purity)
>95% as determined by SDS-PAGE.
制剂(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
作为膜结合配体Jagged-1(JAG1)、Jagged-2(JAG2)和Delta-1(DLL1)的受体,调节细胞命运的决定。当配体通过释放的缺口细胞内结构域(NICD)激活时,它与RBPJ/RBPSHH形成转录激活物复合物,并激活分裂位点增强子的基因。影响分化、增殖和凋亡程序的实施(按相似性)。参与骨重塑和稳态。与RELA/p65合作,增强NFATc1启动子活性,并积极调节RANKL诱导的破骨细胞分化。积极调节癌症细胞的自我更新。
关键字: NOTCH2;NOTCH2蛋白;NOTCH2重组蛋白;ACRO;百普赛斯;
百普赛斯集团ACROBiosystems Group(股票代码:301080)是成立于2010年的跨国生物科技公司,是为全球生物医药、健康产业领域提供关键生物试剂产品及解决方案的行业平台型基石企业。2021年在创业板上市。百普赛斯集团业务遍布全球,横跨亚洲、北美洲、欧洲,在中国、美国、瑞士等12个城市设有办公室、研发中心及生产基地。目前累计服务客户超6000家,与全球Top 20医药企业均建立了长期、稳定的合作伙伴关系。集团旗下拥有品牌ACROBiosystems百普赛斯、bioSeedin柏思荟、Condense Capital垦拓资本和ACRODiagnostics百斯医学等。