Product Name: Terlipressin Acetate
Synonyms: 36T125; D06672; Q324147; DB02638; HS-2028; CS-5769; EX-A3116; HY-12554; SC-47098; J-008213; Variquel; Remestyp; LS-161411; GTPL11241; CCG-270662; 14636-12-5; Glypressin; CHEBI:135905; Tox21_113374; SCHEMBL22699; TERLIPRESSIN; CHEMBL2135460; DTXSID7048952; Lucassin (TN); AKOS015994637; Terlipressina; Terlipressine; Glycylpressin; C52H74N16O15S2; CAS-14636-12-5; TerlipressinuM; NCGC00185754-01; EINECS 238-680-8; DSSTox_CID_28878; DSSTox_RID_83146; DSSTox_GSID_48952; Thymosin α1 Acetate; Thymosin al Acetate; Terlipressin Acetate; Terlipressin [BAN:INN]; Terlipressin (USAN/INN); Terlipressine [INN-French]; Terlipressinum [INN-Latin]; Terlipressina [INN-Spanish]; Terlipressin [USAN:INN:BAN]; Terlipressin Diacetate Salt; Terlipressin acetate, >=98%; Triglycyl-8-lysine-vasopressin; 1-Triglycyl-8-lysine Vasopressin; 130: PN: WO2010033207 SEQID: 171 claiMed protein; N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin; H-Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2; Gly-Gly-Gly-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (disulfide bridge 4:9)
CAS Registry number: 14636-12-5
EINECS:238-680-8
Molecular Formula: C52H74N16O15S2
Boiling Point: 1824 °C at 760 mmHg
Flash Point: 1056.9 °C
Refractive index: 1.664
Density: 1.46
Appearance: White powder
Pharmacological effects: Terlipressin is a novel long-acting synthetic vasopressin reagent,its chemical name is three glycyl lysine vasopressin, it is a prodrug, itself has no activity ,in vivo , it removes three glycyl residues in its N-terminus by aminopeptidase, and slowly "releases" the active lysine vasopressin. It is this "slow release" mechanism that makes it maintain the smooth muscle contraction up to 10 hours after a single administration, whereas the same dose of vasopressin, it can maintain its activity for 20-40 minutes. On the other hand,because of the slow digestion, lysine vasopressin in the circulation cannot reach toxic levels, and usage of terlipressin is safer.
Pharmacological effect of terlipressin is splanchnic vascular smooth muscle contraction, and reduction of visceral blood flow (such as reducing blood flow in the mesentery, spleen, uterus, etc.), thereby reducing portal vein blood flow,and reducing portal pressure, on the other hand it may also reduce plasma renin concentration, thereby increasing the renal blood flow in patients with hepatorenal syndrome, to improve kidney function, and increase urine output. Terlipressin is currently the only drug which is able to increase mortality in patients with esophageal varices bleeding , it is previously mainly used in clinical for the treatment of variceal bleeding, in addition,terlipressin now has also been successfully used for liver and kidney integrated syndrome and refractory shock, it is also likely to play a useful role in the cardiopulmonary resuscitation . Compared with vasopressin, it has a lasting effect, and it does not cause dangerous complications, including promoting fibrinolysis and severe complications in the cardiovascular systems, and the use of it is simple (available intravenous injection), it is more suitable for rescue and treatment of emergent and critical patients.
Uses: N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is used norepinephrine-resistant septic shock and hepatorenal syndrome. N-(N-(N-Glycylglycyl)glycyl)-8-L-lysinevasopressin is also used in the treatment of acute variceal bleeding.
关键字: 原料药与中间体;
一般项目:第二类医疗器械销售;针纺织品及原料批发;服装复试批发;日用百货销售;家用电器销售;第一类医疗器械销售;化工产品销售(不含许可类化工产品);五金产品批发;计算机软硬件及辅助设备批发;化妆品批发;消毒剂销售(不含危险化学品);专用化学产品销售(不含危验化学品);个人卫生用品销售;金属材料售;医用口罩批发;日用口罩(非医用)销售;医护人员防护用品批发;卫生用品和一次性使用医疗用品销售;劳动保护用品确售;合成材料销售;饲料添加剂销售;药物检测仪器销售;制药专用设备销售;财务咨询;信息咨询服务(不含许可类信息咨询服务);技术服务、技术开发、技术咨询、技术交流、技术转让、技术推广;染料销售;卫生用品销售;建筑装饰材料销售;电子办公设备销售;针纺识品销售;贸易经纪;销售代理;国内贸易代理(除依法须经批准的项目外,凭营业执照依法自主开展经营活动)。许可项目∶食品经营(销售预包装食品);货物进出口;药品进出口;进出口代理;技术进出口(依法须经批准的项目,经相关部门批批准方可开展经营活动,具体经营项目以审批结果为准)。