Dyclonine Hydrochloride: An Essential Local Anesthetic in Modern Medicine

Dyclonine Hydrochloride, an unclassified compound with local anesthetic effect. Dyclonine reversibly binds to activated sodium channels on the neuronal membrane, thereby decreasing the neuronal membrane's permeability to sodium ions, leading to an increased threshold for excitation. This reversibly stabilizes the membrane and inhibits depolarization, leading to the failure of a propagated action potential and subsequent conduction blockade. This results in a transient and reversible loss of sensation in a localized area of the body.

Figure 1 Characteristics of Dyclonine hydrochloride

Pharmacodynamics

Dyclonine Hydrochloride is an oral anasthetic. If substantial quantities of local anesthetics are absorbed through the mucosa, actions on the central nervous system (CNS) may cause CNS stimulation and/or CNS depression. Actions on the cardiovascular system may cause depression of cardiac conduction and excitability and, with some of these agents, peripheral vasodilation.

Mechanism of action

Local anesthetics block both the initiation and conduction of nerve impulses by decreasing the neuronal membrane's permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.

Side effects of Dyclonine Hydrochloride

The most common side effects of Dyclonine Hydrochloride are listed below. Tell your healthcare provider if you have any of these side effects that bother you.

• Dizziness

• Dry mouth

• Blurred vision

• Nausea

• Sleepiness

• Feeling unusually weak or tired

• Nervousness

There may be other side effects of Dyclonine Hydrochloride that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine.