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Is 4-Butylresorcinol safe in the treatment of melasma?

Jan 3，2024

4-Butylresorcinol 0.1% Cream has shown rapid efficacy and good tolerability when used in the treatment of melasma. The results of the study showed that the melanin index of 4-Butylresorcinol 0.1% Cream was significantly reduced after 4 weeks (p=0.006) and 8 weeks (p<0.0005) of application, and all the adverse effects were mild and transient. In addition, it is well tolerated by the skin, effectively inhibits tyrosinase, and can be applied not only for long term use, but also during pregnancy.

4-Butylresorcinol

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4-Butylresorcinol: activities, clinical application and safety Aug 4, 2023
4-Butylresorcinol inhibits melanin synthesis, is effective for melasma, but may cause allergies. Patch test before use.
The pharmacologic action and use of 4-butylresorcinol Aug 30, 2019
Hyperpigmentary disorders like melasma, actinic and senile lentigines are a major cosmetic concern. Therefore, many topical products are available, containing various active ingredients aiming to reduce melanin production and distribution.

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4-Butylresorcinol

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