Uses and Synthesize of Clofibrate

Jan 11,2022

Clofibrate has no effect on hyperchylomicronemia, nor does it affect concentrations of high-density lipoproteins (HDL). Thus, clofibrate appears to have specific efficacy only in patients with familial type-III hyperlipoproteinemia. There is no substantial evidence proving efficacy of clofibrate in preventing deaths from coronary artery disease. Clofibrate has been used to prevent or control polydipsia, polyuria, and dehydration in a limited number of patients with mild to moderate neurohypophyseal diabetes insipidus. A 5-year multicenter study reported failure of clofibrate in reducing or preventing mortality in cardiovascular disorders, which has provided a setback for the prophylactic use of this drug.

1.png

Property

Clofibrate is a clear, colorless liquid with a density of 1.14 g ml-1(at 25°C). The boiling point of clofibrate is 148–150°C at 25mmHg. This drug is a stable, colorless to pale-yellow liquid with a faint odor and characteristic taste. Its melting point is below 25°C, it is soluble in common solvents but not in water, and its solubility or log P (octanol/water) is 3.620.

Synthesize

Clofibrate can be chemically synthesized by the condensation of phenol with ethyl 2-chloro-2-methylpropionate in the presence of a dehydrochlorinating agent, followed by chlorination and purification. It can also be synthesized by the condensation of p-chlorophenol with acetone and chloroform followed by esterifying the resultant acid to give clofibrate.

Uses

Clofibrate is a lipid-lowering agent (antilipidemic) used for controlling high cholesterol (anticholesteremic) and triacylglyceride levels in the blood. It increases lipoprotein lipase activity to promote the conversion of VLDL to LDL, thereby reducing VLDL levels. It is indicated only in subjects with increased concentrations of VLDL and intermediate-density lipoproteins (IDL) who have failed to respond adequately to gemfibrozil or nicotinic acid. Clofibrate is of limited utility for patients with either familial hypercholesterolemia or polygenic hypercholesterolemia, as comparatively more effective drugs are available for lowering the concentration of LDL in these patients.

Mechanism

Clofibrate characteristically reduces plasma triglycerides by lowering the concentration of VLDL within 2–5 days after initiation of therapy. In a majority of patients, total cholesterol and LDL concentrations in plasma fall slightly. However, some patients who exhibit a large fall in VLDL may show a paradoxical rise in LDL, resulting in minimal net effect on total cholesterol levels.

The drug has several proposed antilipidemic actions, including increased triglyceride and VLDL clearance, mobilization of cholesterol from tissues, increased fecal excretion of neutral sterols, decreased hepatic lipoprotein synthesis and/or secretion, decreased free fatty acid release, and decreased triglyceride synthesis. The precise mechanisms by which clofibrate lowers serum concentrations of triglycerides and cholesterol are not known.

  • Related articles
  • Related Qustion
See also
4

Chrysene is a polycyclic aromatic hydrocarbon (PAH) with the molecular formula C18H12. It is one of the natural constituents in coal tar, from which it was first isolated and characterized.....

Jan 11,2022Chemical Reagents
4

Chloroacetophenone(CN) was first synthesized in 1870 by the Germans. It is used as a riot control agent (RCA) due to its potency as a lachrymatory agent. It got its fame after World War I when it was given the trade name Mace, the first Ame....

Jan 11,2022Organic Chemistry

Clofibrate

637-07-0

Clofibrate manufacturers

  • Clofibrate
  • 637-07-0 Clofibrate
  • $15.00 / 1KG
  • 2021-07-13
  • CAS:637-07-0
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Clofibrate
  • 637-07-0 Clofibrate
  • $15.00 / 1KG
  • 2021-07-09
  • CAS:637-07-0
  • Min. Order: 1KG
  • Purity: 99%+ HPLC
  • Supply Ability: Monthly supply of 1 ton
  • Clofibrate
  •  637-07-0  Clofibrate
  • $2.00 / 1KG
  • 2019-07-06
  • CAS: 637-07-0
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1ton