What does oleanolic acid used for? Is it safe?

Oleanolic acid, a pentacyclic triterpenoid is isolated from chloroform extract of Olea ferruginea Royle after removal of organic bases and free acids. It is receiving outstanding attention from the scientific community due to its biological activity against multiple diseases.

Biological Activities

Oleanolic acid is a highly potent compound which shows variety of biological activities. It is known for their antimicrobial, hepatoprotective, anti-inflammatory, antiallergic, antiviral and cytotoxic activities. It can be an active ingredient in treating urease, beta-lactamase, acetyl cholinesterase, alpha-glucosidase, antimicrobial, hepatoprotective, anti-inflammatory, antipruritic effects, spasmolytic activity, anti-angiogenic activities, antiallergic, antiviral and cytotoxic activities. 

Oleanolic acid is endowed with a wide range of biological activities with therapeutic potential by means of complex and multifactorial mechanisms. There is evidence suggesting that oleanolic acid might be effective against dyslipidemia, diabetes and metabolic syndrome, through enhancing insulin response, preserving the functionality and survival of β-cells and protecting against diabetes complications.

Side effect

In conclusion, while oleanolic acid offers several potential health benefits, it is not without side effects. Gastrointestinal discomfort, liver toxicity, allergic reactions, hypoglycemic effects, drug interactions, and potential reproductive toxicity are among the concerns associated with its use. As with any supplement, it is crucial to use oleanolic acid responsibly and consult a healthcare professional before starting, especially if you have pre-existing health conditions or are taking other medications. By being informed and cautious, you can better navigate the potential risks and benefits of oleanolic acid.