Пиронаридин химические свойства, назначение, производство
Химические свойства
solid
Антимикробная активность
Pyronaridine is active against the asexual erythrocytic stage of
P. falciparum with little or no activity against gametocytes or the
hepatic stage. In-vitro blood schizonticide activities are in the
range of 0.001–0.03 mg/L, showing a moderate correlation to
chloroquine resistance. However, this correlation varies between
studies and does not seem to be clinically significant. It is also
active against P. vivax, P. ovale and P. malariae. Antagonistic
interactions with artemisinins were reported in vitro, but synergy
with artesunate has been observed in rodent models.
Приобретенная устойчивость
Decreasing in-vitro sensitivity has been observed in China.
Фармацевтические приложения
An aza-aminoacridine formulated for oral use. A Mannichbase
derivative of mepacrine.
Фармакокине?тика
Peak plasma concentrations are reached after 3–14 h depending
upon the formulation; there is also considerable interindividual
variation. Elimination half-lives of 63–190 h have
been reported, again dependent upon the formulation.
Клиническое использование
Treatment of uncomplicated P. falciparum and P. vivax malaria
A fixed-dose combination with artesunate (Pyramax) is being
developed for uncomplicated P. falciparum and P. vivax malaria.
Побочные эффекты
It is well tolerated and no outstanding toxic effects have been
reported.
Пиронаридин препаратная продукция и сырье
сырьё
препарат