Pine needle oil химические свойства, назначение, производство
Химические свойства
Dwarf-pine-needle oil is obtained in Austria (Tyrol) and other
mountainous areas of Central and Southeast Europe by steam distillation of
fresh needles and twig tips of Pinus mugo Turra ssp. mugo and ssp. pumilio
(Haenke) Franco. It is a colorless liquid with a pleasant, balsamic odor.
d2020 0.858–0.868; n20D 1.474–1.478; α20D ?15 ° to ?7 °; solubility: 1 vol in
≤10 vol of 90% ethanol. Content by GC: α-pinene 10–30%;β-pinene 3–14%; 3-carene 5–25%; β-phellandrene 8–17%; limonene 8–14%; bornyl acetate 1–5%.
Физические свойства
It is a clear, almost colorless, mobile liquid.
Вхождение
Found in the branches and adherent leaves of P. mugo Turra var. pumilio (Fam. Pinaceae) (Guenther, 1952).
Подготовка
By steam distillation of the branches and leaves of P. mugo Turra var. pumilio (Guenther, 1952).
Cостав эфирных масел
Main constituents include l-α-pinene, β-pinene, l-limonene, dipentene, l-phellandrene, aldehydes, various
esters, and alcohols.
Фармаколо?гия
In man. Pinus pumilio oil increased bronchial secretions (Thomas, 1958). A dose
of 500 mg/kg was reported to have no effect in vivo on the metabolism and pharmacological activity
of pentobarbitone (25 mg/kg) in rats or in vitro on the metabolism of amidopyrene, p-nitroanisole
and aniline by rat liver (Jori et al. 1969). Intravenous injection of the oil dissolved in sorbitol
monostearate water caused no toxic effects in warm-blooded animals and large doses caused no
changes in blood pressure, but it showed digitalis-like action of the isolated toad heart (Primavori.
1960).
Профиль безопасности
Mildly toxic by
ingestion. A human skin irritant. When
heated to decomposition it emits acrid
smoke and irritating fumes.
Метаболизм
Following immersion of young pigs and one human subject for 30 min in baths containing 150 ml of a pine-oil mixture (Fichtennadel-Latschenkiefer?l. Kneipp) in 450 litres of water, a- and ?-pinene and limonene (components of Latschenkiefer?l) were detected in the exhaled air within 20 min, reaching maximum levels 50-75 min after the start of the bath and remaining detectable after 1 day (R?mmelt, Zuber. Dirnagl. & Drexel. 1974).
Pine needle oil препаратная продукция и сырье
сырьё
препарат