Dynasore
Dynasore атрибут
| Температура плавления: |
>224°C (dec.) |
| плотность: |
1.36±0.1 g/cm3(Predicted) |
| температура хранения: |
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| растворимость: |
Растворим в ДМСО (до 30 мг/мл) или в этаноле (до 1 мг/мл). |
| форма: |
Не совсем белое твердое вещество. |
| пка: |
8.49±0.35(Predicted) |
| цвет: |
Бежевый |
| Стабильность:: |
Растворы в ДМСО или этаноле можно хранить при -20° до 1 месяца. |
| Справочник по базе данных CAS: |
304448-55-3 |
Dynasore химические свойства, назначение, производство
Использование
Dynasore is a cell-permeable, reversible inhibitor of dynamin 1, dynamin 2, and mitochondrial dynamin, Drp1 GTPase activity (IC50 = 15 μM). Through this action, dynasore inhibits clathrin-dependent vesicle formation and endocytosis, which is necessary for internalization of certain parasites and viruses, as well as particles and receptor ligands. In some cases, dynasore can also augment the release of neurotransmitters and secreted cytokines.[Cayman Chemical]
Определение
ChEBI: A carbohydrazide resulting from the formal condensation of the hydrazone moiety of 3,4-dihydroxybenzaldehyde hydrazone with the carboxy group of 3-hydroxy-2-naphthoic acid. It is a cell-permeable, reversible noncompetitive inhibitor of the GTPase activity
f dynamin 1 and 2 and Drp1 (mitochondrial), while exhibiting no significant effect against two other small GTPases, MxA and Cdc42.
Биологическая активность
Non-competitive inhibitor of dynamin 1, dynamin 2 and mitochondrial dynamin (Drp1) GTPase activity. Does not inhibit other small GTPases. Blocks endocytic pathways dependent on dynamin and inhibits cell spreading and migration of BSC1 cells.
Dynasore препаратная продукция и сырье
сырьё
препарат
Dynasore поставщик
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