FMOC-Ala-OH
FMOC-Ala-OH атрибут
| Температура плавления: |
147-153 °C (lit.) |
| альфа: |
-19 º (c=1,DMF) |
| Температура кипения: |
451.38°C (rough estimate) |
| плотность: |
1.2626 (rough estimate) |
| показатель преломления: |
-18.5 ° (C=1, DMF) |
| температура хранения: |
Store below +30°C. |
| растворимость: |
ДМСО (незначительно), ДМФА (незначительно), метанол (незначительно) |
| форма: |
Твердый |
| пка: |
3.91±0.10(Predicted) |
| цвет: |
белый |
| оптическая активность: |
[α]20/D 18°, c = 1 in DMF |
| Растворимость в воде: |
Растворим в воде. |
| БРН: |
2225975 |
| ИнЧИКей: |
QWXZOFZKSQXPDC-NSHDSACASA-N |
| Справочник по базе данных CAS: |
35661-39-3(CAS DataBase Reference) |
FMOC-Ala-OH химические свойства, назначение, производство
Химические свойства
white to light yellow crystal powde
Использование
FMOC-Ala-OH is potentially useful for proteomics studies and solid phase peptide synthesis techniques. Alanine is one of the simplest amino acids - a methyl group as the side chain. This small side chain confers a high degree of flexibility when incorporated into a polypeptide chain. The Fmoc group is typically removed with a base such as pyridine - an orthogonal de-protection strategy to the acid labilie Boc group.
Подготовка
A solution of the Fmoc-OX derivatives (20 mmol) in 100 mL acetone was added dropwise to a stirred solution of Alanine (20 mmol) and NaHCO
3 (50 mmol) in 100 mL water. After stirring overnight the reaction mixture was concentrated under reduced pressure and then extracted with CH
2Cl
2 (50 mL) to remove the unreacted Fmoc-OX derivatives. The reaction mixture was cooled and acidified with 10% HCl to congo red litmus paper to give a white solid, which was filtered and washed with water several times, dried to give a white solid (FMOC-Ala-OH).Yield=89.5%.
FMOC-Ala-OH препаратная продукция и сырье
сырьё
препарат
FMOC-Ala-OH поставщик
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