3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE атрибут
Температура плавления: |
207-209℃ (water acetone ) |
температура хранения: |
room temp |
растворимость: |
H2O: растворим 15 мг/мл, прозрачный |
форма: |
Кристаллический |
цвет: |
белый |
Растворимость в воде: |
почти прозрачность |
Мерк: |
14,9693 |
Справочник по базе данных CAS: |
1005-24-9(CAS DataBase Reference) |
FDA UNII: |
L54XNJ1D5G |
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE химические свойства, назначение, производство
Описание
Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.
Использование
Nicotinamide is a precursor of NAD and NADP , which serve essential functions in modulating cellular redox status and controlling signaling and transcriptional events. 1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced by the action of nicotinamide N-methyltransferase (NNMT; ). It demonstrates antithrombotic and anti-inflammatory properties through direct action on the endothelium by a mechanism involving the prostacyclin pathway and by improving nitric oxide bioavailability. Aggressive cancer cell lines are reported to have higher levels of MNA due to increased NNMT-directed transfer of methyl groups from S-adenosyl-L-methionine to nicotinamide, implicating a role for MNA in cancer cell metabolism.
Общее описание
1-Methylnicotinamide (MNA) is a primary metabolite of nicotinamide produced mainly by nicotinamide N-methyltransferase (NNMT) and exhibits antithrombotic and anti-inflammatory effects.
Методы очистки
Recrystallise it from MeOH. [Beilstein 22 III/IV 468, 22/2 V 80.]
3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE препаратная продукция и сырье
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3-CARBAMYL-1-METHYLPYRIDINIUM CHLORIDE поставщик
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