MEK Inhibitor Set

MEK and ERK signaling are biologically the closest downstream point from RAS and RAF activation; as a result, there is considerable interest in the use of MEK inhibitors in the KRAS mutant population. The evidence of significant synergism and activity of these molecules in combination with RAF inhibition in other subtypes has led to the development of several MEK inhibitors; some as noted below have been explored in KRAS mutant NSCLC.