Cedrol
|
77-53-2
|
- CAS №
- 77-53-2
- английское имя:
- Cedrol
- Синонимы:
- CEDROL CRYSTALS;alpha-Cedrol;(+)-CEDROL;CEDRENOL B;Cedrol crystal;(1S,2R,5S,7R,8R)-2,6,6,8-TETRAMETHYLTRICYCLO[5.3.1.01.5]UNDECAN-8-OL;1H-3a,7-Methanoazulen-6-ol, octahydro-3,6,8,8-tetramethyl-, (3R,3aS,6R,7R,8aS)-;CEDROL;Cedrol >Cedran-8-ol
- CBNumber:
- CB1165544
- Формула:
- C15H26O
- молекулярный вес:
- 222.37
- MOL File:
- 77-53-2.mol
|
Cedrol атрибут
| Температура плавления: |
55-59 °C(lit.) |
| Температура кипения: |
273 °C(lit.) |
| альфа: |
D28 +9.9° (c = 5 in chloroform) |
| плотность: |
0.9479 |
| показатель преломления: |
n20/D1.509-1.515 |
| FEMA: |
4503 | (+)-CEDROL |
| Fp: |
200 °F |
| температура хранения: |
2-8°C |
| растворимость: |
Растворим в ДМСО (10 мг/мл) |
| пка: |
15.35±0.60(Predicted) |
| форма: |
Solid |
| цвет: |
белый |
| Запах: |
at 100.00 %. cedarwood woody dry sweet soft |
| Odor Type: |
woody |
| оптическая активность: |
[α]20/D +10.5±1°, c = 5% in chloroform |
| Номер JECFA: |
2030 |
| Мерк: |
14,1911 |
| БРН: |
2206347 |
| Стабильность:: |
Стабильный в течение 1 года с даты покупки при поставке. Растворы в ДМСО можно хранить при температуре -20°С до 3 месяцев. |
| LogP: |
4.33 |
| Вещества, добавляемые в пищу (ранее EAFUS): |
(+)-CEDROL |
| Справочник по базе данных CAS: |
77-53-2(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG: |
1 |
| FDA UNII: |
63ZM9703BO |
| Справочник по химии NIST: |
Cedrol(77-53-2) |
| Система регистрации веществ EPA: |
1H-3a,7-Methanoazulen-6-ol, octahydro-3,6,8,8-tetramethyl-, (3R,3aS,6R,7R,8aS)- (77-53-2) |
Cedrol химические свойства, назначение, производство
Химические свойства
Colorless crystals; cedarwood odor. soluble in 11 parts of 95% alcohol. Combustible.
Вхождение
Found in the wood of several conifers, particularly cypresses and cedars, including Cedrus atlantica, Cupressus sempervirens, Juniperus virginiana (Fenarolfs Handbook of Flavor Ingredients, 1971).
Использование
(+)-Cedrol can be used as a starting material for the preparation of cedryl acetate by acetylation using acetic anhydride in the presence of an acid catalyst. It can also be incorporated as a precursor for the total synthesis of rare illicium sesquiterpene (+)-pseudoanisatin via selective C-H bond functionalization.
Подготовка
From cedarwood by fractional distillation followed by recrystallization from suitable solvents of appropriate solid fractions.
Определение
A tertiary terpene alcohol.
Общее описание
(+)-Cedrol is a crystalline hydrated product of α-cedrene, which is a sesquiterpene found in cedar-wood oil. It can be used as a fragrance ingredient in cosmetics, shampoos, and soaps as well as in non-cosmetic products such as cleaners and detergents. (±) Cedrol can be synthesized by intramolecular Diels-Alder reaction of alkyl cyclopentadiene.
Методы очистки
Purify cedrol by recrystallisation from aqueous MeOH. It is estimated colorimetrically with H3PO4 in EtOH followed by vanillin and HCl [Hayward & Seymour Anal Chem 20 572 1948]. The 3,5-dinitrobenzoyl derivative has m 92-93o. [Stork & Clarke J Am Chem Soc 83 3114 1961, Beilstein 6 III 424.]
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