Оксифенбутазон
Оксифенбутазон атрибут
| Температура плавления: |
109-111°C |
| Температура кипения: |
462.71°C (rough estimate) |
| плотность: |
1.2118 (rough estimate) |
| показатель преломления: |
1.6140 (estimate) |
| температура хранения: |
-20°C |
| растворимость: |
ДМСО: растворимый 10 мг/мл, прозрачный |
| пка: |
pKa 4.7/10.0±0.2(H2O,t =25,Iundefined) (Uncertain) |
| форма: |
пудра |
| цвет: |
От белого до коричневого |
| Растворимость в воде: |
20 мг/л (комнатная температура) |
| Стабильность:: |
Hygroscopic |
| Справочник по базе данных CAS: |
129-20-4(CAS DataBase Reference) |
| Рейтинг продуктов питания EWG: |
1 |
| FDA UNII: |
A7D84513GV |
| Код УВД: |
M01AA03,M02AA04,S01BC02 |
| МАИР: |
3 (Vol. 13, Sup 7) 1987 |
| Система регистрации веществ EPA: |
3,5-Pyrazolidinedione, 4-butyl-1-(4-hydroxyphenyl)-2-phenyl- (129-20-4) |
Оксифенбутазон химические свойства, назначение, производство
Химические свойства
Light Beige Solid
Использование
Anti-inflammatory;Cyclooxygenase inhibito
Показания
Oxyphenbutazone (Oxalid, Tandearil) is the principal
uricosuric metabolite of phenylbutazone. It has the
same indications and toxicities as phenylbutazone.
Определение
ChEBI: A metabolite of phenylbutazone obtained by hydroxylation at position 4 of one of the phenyl rings. Commonly used (as its hydrate) to treat pain, swelling and stiffness associated with arthritis and gout, it was withdrawn from the market 1984 following asso
iation with blood dyscrasis and Stevens-Johnson syndrome.
Всемирная организация здравоохранения(ВОЗ)
Oxyphenbutazone, a pyrazolone derivative with anti-inflammatory,
analgesic and antipyretic activity, was introduced in 1955 for the treatment of
rheumatic disorders. It is one of the active metabolites of phenylbutazone and has
a similar spectrum of activity including an association with serious and sometimes
fatal adverse reactions, notably cases of aplastic anaemia and agranulocytosis.
Many national drug regulatory authorities consider that more recently introduced drugs offer a safer alternative for most, if not all, patients requiring
antiinflammatory agents. Although oxyphenbutazone has been widely withdrawn it
remains available in some countries.
Общее описание
Oxyphenbutazone is a derivative compound of phenylbutazone. Oxyphenbutazone is one of the metabolites
formed in the liver following administration of
phenylbutazone. Given orally it causes fewer
gastrointestinal adverse effects than phenylbutazone and is used at 300 – 400 mg/d for the same
indications as the parent drug.
Оксифенбутазон препаратная продукция и сырье
сырьё
препарат
Оксифенбутазон поставщик
Global( 60)Suppliers
129-20-4(Оксифенбутазон)подобный поиск: